NRSC4455 - Neuronal identity: practical and conceptual implications

What does it mean to be a cell with a specific role in the nervous system? This question has long intrigued developmental and theoretical neuroscientists and will be the intellectual point of departure for this course. As -omics technologies (such as transcriptomics, proteomics, and genomics) continue to rapidly evolve at both single-cell and population levels, our understanding of neuronal taxonomies has deepened significantly. In this course, students will identify and reflect on the limitations, advantages, and inconsistencies precipitated by such insights. Additionally, as our ability to more precisely define cell types grows, so do the possibilities for targeted therapies. Discussions will encompass the implications of neuronal identity in neurological diseases, examining how disruptions in specific cell types can lead to various pathologies, and how this knowledge is driving the development of targeted therapies. Students will engage and draw understanding from a broad range of fields, such as developmental neuroscience, evolutionary neuroscience, and cell biology. Students will write several short reflection papers, facilitate weekly journal club sessions, and engage in a group debate. Previous background in developmental neuroscience and/or biology is recommended.