This course examines the history, rationale and putative mechanism of action of drugs used in the treatment of psychiatric disorders. Emphasis is placed on neurobiological processes underlying psychopathology and pharmacological intervention. Drugs currently in use as well as new drugs in development will be covered. Strategies, techniques, issues and challenges of clinical psychopharmacological research will be addressed and new approaches to drug discovery, including the use of pharmacogenomics and proteomics to understand variability in drug response and identify new molecular drug targets, will be covered in depth. Specific drug classes to be considered include antidepressants, anxiolytics, typical and atypical antipsychotics, narcotic analgesics, sedative hypnotics, and antiepileptic medications. A contrasting theme throughout the course will be the use of drugs as probes to identify neural substrates of behavior.

This course will familiarize students with advances in our understanding of the clinical features and pathogenesis of a wide range of neurodegenerative diseases, including Alzheimer's disease and other dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motoneuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases. Students will analyze original research reports on a range of proposed pathological cellular processes that may represent steps in cell dealth pathways leading to neuron loss seen in these diseases. Significant emphasis will be placed on the fast-expanding fieldexploring genetic contributions to neurodegenerative disease, as identification of genetic mutations pathogenenic for familial neurodegenerative diseases has been a major driving force in neurodegenerative research and pointed researchers towards essential molecular process that may underlie these disorders. Strategies for therapeutic intervention in the management, prevention, and cure of neurodegenerative disease will be addressed.

What does it mean to be a cell with a specific role in the nervous system? This question has long intrigued developmental and theoretical neuroscientists and will be the intellectual point of departure for this course. As -omics technologies (such as transcriptomics, proteomics, and genomics) continue to rapidly evolve at both single-cell and population levels, our understanding of neuronal taxonomies has deepened significantly. In this course, students will identify and reflect on the limitations, advantages, and inconsistencies precipitated by such insights. Additionally, as our ability to more precisely define cell types grows, so do the possibilities for targeted therapies. Discussions will encompass the implications of neuronal identity in neurological diseases, examining how disruptions in specific cell types can lead to various pathologies, and how this knowledge is driving the development of targeted therapies. Students will engage and draw understanding from a broad range of fields, such as developmental neuroscience, evolutionary neuroscience, and cell biology. Students will write several short reflection papers, facilitate weekly journal club sessions, and engage in a group debate. Previous background in developmental neuroscience and/or biology is recommended.

This course examines neurobiological mechanisms of autism spectrum disorder (ASD). The cognitive neuroscience literature on autism will be roughly categorized around major theoretical models and their relation to autism, focusing on cognitive neuroscience and functional brain imaging, along with some structural imaging and EEG.

This seminar will focus on how immune and central nervous systems communicate and influence each other. We begin with the anatomical and cellular basis of the thymus, gut, and brain, then discuss the connection between these organs and how these connections can influence neurological disorders. The class includes lectures, analysis of scientific literature, class discussions, and journal presentations. The course requires no prior knowledge of neuroimmunology, but understanding of basic neuroscience and immunology principles will be assumed.

In this lab course, a small number of students meet once per week to discuss topics in synaptic physiology and to become proficient at sharp electrode techniques for intracellular recording, using isolated ganglia from the snail Heliosoma. The first part of each class will consist of discussion of weekly reading from the primary literature, with the remainder of the class devoted to hands-on experiments. After learning to record from and characterize single neurons, students will study synaptic transmission by stimulating incoming nerve trunks or by recording from pairs of interconnected neurons. As a midterm assignment, students will prepare and present a short research proposal using this model system, to be evaluated by the class. For the last half of the course, the class will work together on one or two of these proposals, meeting at the end of each class to pool our data, analyze the results and discuss their significance.

This course will allow students to understand the variety, function, and evolution of complex behaviors in simple animals and how the genes governing these behaviors can be used to provide insight into human behavior and brain disease. The course is structured to allow students to experience what it is like to work in a neuroscience research laboratory. We will use the fruit fly (Drosophila melanogaster) as our model organism (with one class dedicated to song birds). Over the course of the semester, we will examine the underlying neurobiology, physiology, and genetics of a variety of fly behaviors to understand aggression, taste, learning and memory, courtship, neurodegenerative diseases, and circadian rhythms. We will review both current and historical research advances in detail by focusing on primary literature. Students will be expected to design, analyze and interpret the behavioral experiments that are employed. Students will learn how to conduct animal behavior research, enhance their ability to critically read scientific literature, and improve their written and oral communication skills through paper presentations and written reports.

This course will introduce students to neuroeconomics, a field of research that combines economic, psychological, and neuroscientific approaches to study decision-making. The course will focus on our current understanding of how our brains give rise to decisions, and how this knowledge might be used to constrain or advance economic and psychological theories of decision-making. Topics covered will include how individuals make decisions under conditions of uncertainty, how groups of individuals decide to cooperate or compete, and how decisions are shaped by social context, memories, and past experience.

The course will begin with a review of basic concepts in pharmacology including: routes of drug administration, drug metabolism, the dose response curve, tolerance and sensitization. Following a brief overview of cellular foundations of neuropharmacology (neuronal biology, synaptic and receptor function), the course will focus on several neurotransmitter systems and the molecular and behavioral mechanisms mediating the mind-altering, additive and neuropsychiatric disorders, including depression, schizophrenia and anxiety with an emphasis on their underlying neurobiological causes, as well as the pharmacological approaches for treatment.

The study of the neural systems that underlie human perception, memory and language; and of the pathological syndromes that result from damage to these systems.